Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 4, Pages 488-496Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.06.006
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Funding
- National Institutes of Health/National Institute of Allergy and Infectious Diseases [R01AI064001, R01AI089246]
- Alexandrine and Alexander L. Sinsheimer Fund
- Clinical and Translational Science Award [UL1RR029887]
- Agence Nationale de Recherche sur le SIDA et les Hepatites Virales [ANRS EP36]
- Sidaction
- Pasteur Institute
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HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.
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