Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 5, Pages 601-608Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.08.007
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Funding
- Tumorzentrum Heidelberg Mannheim [D 100 27 963]
- Swiss National Science Foundation [3200B0 103640]
- European Community [MUGEN LSHG CT 2005 005203]
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Naive T cells spend most of their time scanning the surface of dendritic cells (DCs) indicating that self-MHC/T cell receptor (TCR) interactions between these immune cells occur routinely in peripheral organs during the steady state Peripheral self-MHC recognition on DCs drives seemingly opposing effects in the absence of inflammatory stimuli such as deletion of certain self-reactive T cells as well as maintenance of the T cell responsiveness to antigen both of which shape the T cell repertoire and regulate T cell responses Here we review recent data on the role of self-MHC recognition on steady-state DCs in the periphery and propose that interactions between T cells and steady-state DCs display an analogy with F. election processes that occur in the thymus high affinity TCR/self-MHC interactions in the periphery result in T cell deletion while low/intermediate affinity interactions result in tonic TCR signalling that is required to keep T cells responsive to antigen
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