Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 22, Issue 2, Pages 251-257Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2010.01.020
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Funding
- NIH [PO1 CA94237, P50CA126752, U54HL081007]
- Leukemia Lymphoma Society
- Doris Duke Distinguished Clinical Scientist Award
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Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.
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