Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 4, Pages 425-430Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.06.001
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Funding
- NIH [AG-23717, AG28586]
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Ability to make an optimal immune response to vaccines and infectious agents declines with age in humans and animal models. Recent advances have shown intrinsic B cell defects in aged mice and humans, including decreases in Ig class switch recombination (CSR), activation-induced cytidine deaminase (AID), and E47 transcription factor. Effects on somatic hypermutation (SHM) have been varied depending on the system studied. Increase of AID in mice has shown improved CSR but not SHM. The reported microarray analysis of human B cell subsets may now be used to delineate B cell defects with aging and all the advances presented should lead to selecting agents for improved immune response in the elderly.
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