Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 1, Pages 10-16Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.01.006
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Funding
- National Institutes of Health [K08 A1065517, K08 A1067736]
- Centers for Disease Control and Prevention [K01 CK000101]
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The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular sensors is a crucial component of the innate immune system. A number of NLR family members can form multiprotein complexes, called inflammasomes, and are capable of activating the cysteine protease caspase-1 in response to a wide range of stimuli including both microbial and self-molecules. Caspase-1 activation leads to processing and secretion of the proinflammatory cytokines interleukin-1 beta (IL-1 beta) and IL-18, which play crucial roles in host defense to infectious insults. Dysregulation of the inflammasome has also been linked to a number of autoinflammatory and autoimmune disorders. Recent advances in the inflammasome field will be discussed in this review.
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