Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 1, Pages 63-67Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.01.011
Keywords
-
Categories
Funding
- NHLBI NIH HHS [R01 HL091531, R01 HL091531-02] Funding Source: Medline
- NIDDK NIH HHS [R01 DK065029-05, R01 DK065029] Funding Source: Medline
Ask authors/readers for more resources
Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders. Some microbes have evolved effective countermeasures that blunt the effect of iron restriction. Recent epidemiologic studies have highlighted the potentiating effect of iron on microbial infections. Laboratory studies have focused on specific immune mechanisms that mediate iron withholding from microbes constitutively and in response to infections. Specialized inflammation-regulated proteins chelate iron, trap siderophores, and transport iron or modulate its transport to alter its tissue distribution during infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available