Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 1, Pages 3-9Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.01.007
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Funding
- NIH [PO1 A1070167]
- ANR (Microbiologie-Maladies emergentes)
- CNRS
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Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.
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