Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 2, Pages 133-139Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.03.009
Keywords
-
Categories
Funding
- National Institutes of Health [R37 GM41052, RO1 A149934]
Ask authors/readers for more resources
The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assembled by V(D)J recombination according to distinct programs during intrathymic T cell development. These programs depend on genetic factors, including gene segment order and recombination signal sequences. They also depend on epigenetic factors. Regulated changes in chromatin structure, directed by enhancers and promoter, can modify the availability of recombination signal sequences to the RAG recombinase. Regulated changes in locus conformation may control the synapsis of distant recombination signal sequences, and regulated changes in subnuclear positioning may influence locus recombination events by unknown mechanisms. Together these influences may explain the ordered activation and inactivation of T cell receptor locus recombination events and the phenomenon of Tcrb allelic exclusion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available