Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 6, Pages 634-640Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.09.012
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Funding
- Swedish Research Council
- Swedish Cancer Society
- Swedish Society for Medical Research
- Swedish Strategic Research Foundation
- European Union
- Juvenile Diabetes Research Foundation
- Karolinska Institutet
- Karolinska University Hospital
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Natural killer (NK) cells are innate immune cells. Although INK cells are best characterized for their ability to control tumors and infections, recent data have indicated that they also are important regulatory cells by virtue of interactions with many types of immune and nonimmune cells. Thereby, they can affect the outcome of adaptive immune responses and maintain immune homeostasis. Thus, NK cells can either exacerbate or limit immune responses, including those to autoantigens. Here, we discuss current insights into the role of NK cells in human autoimmunity.
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