Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 21, Issue 2, Pages 140-145Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2009.02.008
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Funding
- Stanford Graduate Fellowship (SGF)
- National Institues of Health (NIH) Cell and Molecular Biology (CMB) [A1 33431, U19 A1 67229]
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gamma delta T cells contribute uniquely to host immune defense, but how they do so remains unclear. Recent work suggests that thymic selection does little to constrain gamma delta T cell antigen specificities, but instead determines their effector fate. When triggered through the T cell receptor, ligand-experienced cells make IFN gamma, whereas ligand-naive gamma delta T cells produce IL-17, a major initiator of inflammation. These advances warrant a fresh look at how gamma delta T cells may function in the immune system.
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