Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 20, Issue 3, Pages 332-338Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.03.003
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Funding
- NIAID NIH HHS [R01 AI068056-03, R01 AI050844-05, R01 AI068056, R01-AI0688056, R01 AI050844] Funding Source: Medline
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The successful use of B cell depletion therapy for the treatment of autoimmune disease has led to a resurgent appreciation of B cells as powerful regulators of immunity. However, to the surprise of many, B cells appear to regulate autoimmune conditions independently of their ability to produce autoantibodies. Indeed, disturbances in the ability of B cell subsets to present antigen, produce cytokines, and regulate the activities of T cells is emerging as a key feature in many inflammatory diseases. Here we review the recent literature describing cytokine-producing regulatory and effector B cell subsets in health and disease and discuss how future B cell-directed therapies might target the pathologic cytokine-producing effector B cell subsets without impacting the protective regulatory subsets.
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