Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 20, Issue 1, Pages 61-67Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.10.009
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For years, dendritic cell (DC) biologists have oscillated between two seemingly antagonistic ideas: functional specialization (division of labor) of DC subsets and plasticity (multitasking). More recently, a third hypothesis is gathering support: crosstalk between functionally distinct DC subsets. This reveals a previously unappreciated hierarchy of organization within the DC system, and provides a conceptual framework to understand how cooperation between functionally distinct, yet plastic, DC subsets can shape adaptive immunity and immunological memory. Here we review the recent advances in this area.
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