Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 20, Issue 5, Pages 538-544Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.05.004
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Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC)
- Telethon
- Ministero Universita e Ricerca (MUR)
- Ministero della Salute - Alleanza Contro il Cancro, Progetto Finalizzato Oncologia
- European Union
- Fondazione CARIPLO
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Tissue damage elicits an inflammatory response, which comprises the rapid synthesis of acute phase molecules. The early local response shapes the resolution of inflammation. Pentraxins are evolutionary conserved soluble pattern recognition receptors, produced in the liver (e.g. C-reactive protein) or at sites of inflammation (the long pentraxin PTX3). Pentraxins behave as flexible adaptors of innate cell functions, complement activation and clearance of cell and matrix debris, regulating tissue hyperplasia and scarring and limiting the risk of autoimmunity associated to unscheduled cell death in vivo.
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