Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 20, Issue 6, Pages 663-668Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2008.09.003
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Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGF beta acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of ROR gamma-dependent Th17 cells. IL-23 - a member of the IL-12 family - activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when cysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 - another IL-12 family member - plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
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