Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 20, Issue 1, Pages 75-81Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2007.12.005
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Funding
- Cancer Research UK [10601] Funding Source: Medline
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The acquisition of an optimal peptide ligand by MHC class I molecules is crucial for the generation of immunity to viruses and tumors. This process is orchestrated by a molecular machine known as the peptide loading complex (PLC) that consists of specialized and general ER-resident molecules. These proteins collaborate to ensure the loading of an optimal peptide ligand into the antigen binding cleft of class I molecules. The surprising diversity of peptides bound to MHC class I molecules and recapitulation of class I assembly in vitro have provided new insights into the molecular machinations of peptide loading. Coupled with the extraordinary polymorphism of class I molecules and their differential dependence on various components of the PLC for cell surface expression, a picture of peptide loading at the molecular level has recently emerged and will be discussed herein.
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