Journal
CURRENT OPINION IN HEMATOLOGY
Volume 20, Issue 1, Pages 10-15Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e32835b06be
Keywords
apoptosis; CDK inhibitors; inflammation; neutrophils
Categories
Funding
- MRC [MR/K00414X/1] Funding Source: UKRI
- Medical Research Council [MR/K00414X/1] Funding Source: Medline
Ask authors/readers for more resources
Purpose of review Neutrophils are a key component of innate immunity. At sites of infection, they unleash cytotoxic molecules allowing them to kill invading pathogens. However, these molecules can also be deleterious to the host tissue. Therefore, neutrophils undergo apoptosis and are removed from the site of infection following elimination of the pathogen. When neutrophil apoptosis is significantly delayed, this can result in chronic inflammation. This review highlights recent advances in our understanding of neutrophil apoptosis, and discusses literature surrounding the induction of neutrophil apoptosis as a therapeutic strategy for the treatment of chronic inflammatory disease. Recent findings Recent studies have highlighted the role of cyclin-dependent kinases (CDKs) in the regulation of neutrophil lifespan. CDK activity appears to be involved in the maintenance of levels of Mcl-1, an antiapoptotic Bcl-2 family member. In addition, recent findings have demonstrated the induction of neutrophil apoptosis at sites of infection by bystander immune cells including T-regulatory cells (Tregs) and natural killer (NK) cells. Summary Recent advances in our understanding of the processes involved in neutrophil apoptosis, coupled with new insights into the mechanisms by which bystander immune cells induce neutrophil death, may provide novel and exciting possibilities with regards to the treatment of chronic inflammatory diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available