Journal
CURRENT OPINION IN HEMATOLOGY
Volume 18, Issue 4, Pages 208-213Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e3283475ffe
Keywords
hematopoietic stem cell; hypoxia; mitochondrial permeability transition pore; reactive oxygen species; transplantation
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Funding
- Public Health Service [NIH R01 HL56416, NIH R01 HL67384]
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Purpose of review Reactive oxygen species (ROS) have an important function in blood cell homeostasis and hematopoietic diseases. Recent discoveries concerning how ROS are generated and regulated in mitochondria via the mitochondrial permeability transition pore (mPTP) and the new phenomenon, superoxide flashes, and ROS-induced ROS release, have not been investigated in hematopoietic stem and progenitor cells, but likely have important implications for their regulation and survival. Here we relate our opinions about these potential implications. Recent findings The mPTP has been recently implicated in ROS generation via binding of Stat3 transcription factor to a central component of the pore. Summary The implications of this new information for hematopoiesis regulation and transplantation methodologies could prove to be important, especially as they relate to myeloid neoplasm oncogenesis and potentially new therapeutic targets. New details about ROS production suggest that techniques for bone marrow and umbilical cord blood harvest may benefit from means to downmodulate ROS.
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