Journal
CURRENT OPINION IN HEMATOLOGY
Volume 17, Issue 2, Pages 79-84Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e3283366b7a
Keywords
acute myeloid leukemia; dose intensification; induction therapy; targeted therapy
Categories
Ask authors/readers for more resources
Purpose of review Acute myeloid leukemia (AML) is a heterogeneous group of clonal disorders which is treated with similar regimens despite the heterogeneity. The treatment approach for many years has used combination chemotherapy, with usually an anthracycline and cytarabine as the foundation. In the present review we will present new data from recently completed trials that have demonstrated advances in the treatment of AML. Recent findings We will discuss the recent trials that support the importance of dose intensification in younger patients either through increasing dose of the anthracycline, adding other agents such as gemtuzumab ozogamicin, or through 'timed sequential' therapy. We will promote the importance of treating the older AML patient (>60 years old) and the various ways different groups are addressing a different biologically behaving disease and the patient being treated. These methods include dose reduction, dose intensification and new agents with a better toxicity profile. Summary Due to aggressive induction therapy, patients with AML are having better remission and survival outcomes. New agents that are targeted to specific molecular abnormalities in the AML cell are being studied as additions to induction therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available