Journal
CURRENT OPINION IN HEMATOLOGY
Volume 16, Issue 2, Pages 98-104Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MOH.0b013e3283257adb
Keywords
acute myeloid leukemia; all-trans retinoic acid; FLT3-internal tandem duplication; nucleophosmin; predictive markers
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Funding
- Bundesministerium fur Bildung und Forschung [01G19981, 01KG0605]
- Deutsche Jose Carreras Leukamie-Stiftung [DJCLS R06/06v]
- Else Kroner-Fresenius-Stiftung [P38/05//A49/05//F03]
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Purpose of review In recent years, new molecular markers have emerged as significant prognostic parameters and as potential targets for molecularly targeted therapy in acute myeloid leukemia (AML). However, prognostic markers cannot guide the decision for a specific treatment, as they are associated with a differential outcome regardless of the given treatment. In contrast, predictive markers indicate a treatment benefit in patients that are characterized through these markers. Thus, predictive markers can guide clinical decision-making. Recent findings In young adults, mutations of the nucleophosmin (gene gNPM1(mut)) in the absence of concurrent FLT3-internal tandem duplication (ITD) (FLT3-ITDneg) have impressive prognostic and, beyond prognostication, predictive properties. This NPM1(mut)/FLT3-ITDneg genotype predicts equivalent favorable outcome after intensive chemotherapy and allogeneic stem cell transplantation, whereas in the absence of this marker clinical outcome was significantly improved after an allogeneic transplantation. In addition, within a retrospective study performed on older adults, the same genotype predicted a significantly improved outcome if all-trans retinoic acid was added to intensive chemotherapy. Summary The discovery of new prognostic and predictive markers has increased our understanding of leukemogenesis and this may lead to improved prognostication and, more important, to novel genotype-specific treatment strategies.
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