Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 51, Issue -, Pages 78-87Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2018.07.004
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Funding
- Wellcome Trust [099234/Z/12/Z]
- CNRS PICS
- CNRS [GDR 3570 MecaBio, GDR 3070 CellTiss]
- Ministerio de Economia y Competitividad [BFU2014-59438-P]
- [ANR-11-LABX-0030]
- BBSRC [BB/J010278/1] Funding Source: UKRI
- Wellcome Trust [099234/Z/12/Z] Funding Source: Wellcome Trust
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We review recent developments in the understanding of the biomechanics of apicomedial actomyosin and how its contractility can tense and deform tissue. Myosin pulses are driven by a biochemical oscillator but how they are modulated by the mechanical context remains unclear. On the other hand, the emergence of tissue behaviour is highly dependent on the material properties of actin, on how strongly components are connected and on the influence of neighbouring tissues. We further review the use of constitutive equations in exploring the mechanics of epithelial apices dominated by apicomedial Myosin contractility.
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