Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 29, Issue -, Pages 90-96Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.08.013
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Funding
- Strategic Priority Research Program of the Chinese Academy-of Sciences [XDB13010400]
- National Key Basic Research Program of China [2013CB531200]
- National Natural Science Foundation of China [91331114, 31322050]
- NIH [R01GM100768-01A1]
- NSF from National Institutes of Health [1051826]
- NSF from National Science Foundation in USA [1051826]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1051826] Funding Source: National Science Foundation
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New genes in human genomes have been found relevant in evolution and biology of humans. It was conservatively estimated that the human genome encodes more than 300 human-specific genes and 1000 primate-specific genes. These new arrivals appear to be implicated in brain function and male reproduction. Surprisingly, increasing evidence indicates that they may also bring negative pleiotropic effects, while assuming various possible biological functions as sources of phenotypic novelties, suggesting a non-progressive route for functional evolution. Similar to these fixed new genes, polymorphic new genes were found to contribute to functional evolution within species, for example, with respect to digestion or disease resistance, revealing that new genes can acquire new or diverged functions in its initial stage as prototypic genes. These progresses have provided new opportunities to explore the genetic basis of human biology and human evolutionary history in a new dimension.
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