Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 26, Issue -, Pages 131-140Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.07.003
Keywords
-
Categories
Funding
- National Institutes of Health [ES020766-01, CA092584, NS060115]
Ask authors/readers for more resources
Trinucleotide repeats (TNRs) expansion disorders are severe neurodegenerative and neuromuscular disorders that arise from inheriting a long tract (30-50 copies) of a trinucleotide unit within or near an expressed gene (Figure la). The mutation is referred to as 'trinucleotide expansion' since the number of triplet units in a mutated gene is greater than the number found in the normal gene. Expansion becomes obvious once the number of repeating units passes a critical threshold length, but what happens at the threshold to render the repeating tract unstable? Here we discuss DNA-dependent and RNA-dependent models by which a particular DNA length permits a rapid transition to an unstable state.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available