Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 26, Issue -, Pages 33-40Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.05.004
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Funding
- NIA NIH HHS [R01 AG023806, P01 AG036695, R01 AG047820, T32 AG047126] Funding Source: Medline
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A common concept in aging research is that chronological age is the most important risk factor for the development of diverse diseases, including degenerative diseases and cancers. The mechanistic link between the aging process and disease pathogenesis, however, is still enigmatic. Nevertheless, measurement of lifespan, as a surrogate for biological aging, remains among the most frequently used assays in aging research. In this review, we examine the connection between 'normal aging' and age-related disease from the point of view that they form a continuum of aging phenotypes. This notion of common mechanisms gives rise to the converse postulate that diseases may be risk factors for accelerated aging. We explore the advantages and caveats associated with using lifespan as a metric to understand cell and tissue aging, focusing on the elucidation of molecular mechanisms and potential therapies for age-related diseases.
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