Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 26, Issue -, Pages 24-32Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.05.005
Keywords
-
Categories
Funding
- NIH [GM093072-01, DK088190-01A1, CA175727-01A1]
- National Pancreatic Foundation
Ask authors/readers for more resources
Cells evolve to actively coordinate nutrient availability with cellular activity in order to maintain metabolic homeostasis. In addition, active pathways to repair DNA damage are crucial to avoid deleterious genomic instability. In recent years, it has become increasingly clear that availability of intermediate metabolites may play an important role in DNA repair, suggesting that these two seemingly distant cellular activities may be highly coordinated. The sirtuin family of proteins now described as deacylases (they can also remove acyl groups other than acetyl moieties), it appears to have evolved to control both metabolism and DNA repair. In this review, we discuss recent advances that lay the foundation to understanding the role of sirtuins in these two biological processes, and the potential crosstalk to coordinate them.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available