Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 26, Issue -, Pages 124-130Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2014.06.006
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Funding
- European commission [FP7-Health-2008-200880, LSHG-CT-2005-512113]
- National Institute of Health (NIH)/National Institute of Ageing (NIA) [1PO1 AG-17242-02]
- NIEHS [1UO1 ES011044]
- Royal Academy of Arts and Sciences of the Netherlands
- European Research Council [ERC-2008-AdG-233424]
- European Community [HEALTH-F2-2010-259893]
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Recent advances have identified accumulation of DNA damage as a major driver of aging. However, there are numerous kinds of DNA lesions each with their own characteristics and cellular outcome, which highly depends on cellular context: proliferation (cell cycle), differentiation, propensity for survival/death, cell condition and systemic hormonal and immunological parameters. In addition, DNA damage is strongly influenced by cellular metabolism, anti-oxidant status and exogenous factors, consistent with the multi-factorial nature of aging. Notably, DNA lesions interfering with replication have very different outcomes compared to transcription. These considerations provide a conceptual framework in which different types of DNA damage and their setting contribute to the aging process in differential manners.
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