Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 23, Issue 1, Pages 29-34Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.12.004
Keywords
-
Categories
Funding
- NIH [P01 HL029582, P01 HL076491, R01 GM086430]
- National Center Scientist Development Grant from the American Heart Association [10SDG3930003]
- American Heart Association, Great Rivers Affiliate
Ask authors/readers for more resources
Translational control provides numerous advantages in regulation of gene expression including rapid responsiveness, intracellular localization, nondestruction of template mRNA, and coordinated regulation of transcript ensembles. Transcript-selective, translational control is driven by the specific interaction of factor(s) with the 5' or 3' untranslated region (UTR), thereby influencing initiation, elongation, or termination of mRNA translation. The mean length of human 3'UTRs is greater than that of 5'UTR, indicating the expanded potential for motifs, structural elements, and binding sites for trans-acting factors that exert transcript-selective translation control. New and unexpected mechanisms of 3'UTR-mediated translational control and their contributions to disease have received increasing attention during the last decade. Here, we briefly review a few recent and representative discoveries of 3'UTR-mediated translational control, emphasizing the novel aspects of these regulatory mechanisms and their potential pathophysiological significance.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available