Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 23, Issue 2, Pages 174-184Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.12.008
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Funding
- Novartis Research Foundation
- Marie Curie network Image-DDR
- Marie Curie network Nucleosome 4D
- Swiss National Science Foundation
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ATP-dependent nucleosome remodelers use ATP hydrolysis to shift, evict and exchange histone dimers or octamers and have well-established roles in transcription. Earlier work has suggested a role for nucleosome remodelers such as INO80 in double-strand break (DSB) repair. This review will begin with an update on recent studies that explore how remodelers are recruited to DSBs. We then examine their impact on various steps of repair, focusing on resection and the formation of the Rad51-ssDNA nucleofilament. Finally, we will explore new studies that implicate remodelers in the physical movement of chromatin in response to damage.
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