Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 23, Issue 2, Pages 81-88Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2013.01.001
Keywords
-
Categories
Funding
- Biotechnology and Biological Sciences Research Council (BBSRC) studentship
- BBSRC
- Medical Research Council
- Biotechnology and Biological Sciences Research Council [BBS/E/B/000C0405, BBS/E/B/0000M257, BBS/E/B/000C0404] Funding Source: researchfish
- Medical Research Council [G0901034] Funding Source: researchfish
- BBSRC [BBS/E/B/0000M257, BBS/E/B/000C0405, BBS/E/B/000C0404] Funding Source: UKRI
- MRC [G0901034] Funding Source: UKRI
Ask authors/readers for more resources
The enormous antigen receptor loci in lymphocytes are a paradigm of dynamic nuclear organisation, which is integral to their need to move extensively in 3D space to achieve distal gene synapse for V(D)J recombination and allelic exclusion. The loci undergo extensive 3D looping to bring distal genes together, controlled by several tissue-specific and ubiquitous factors, but how these factors achieve looping, synapsis and V(D)J recombination has been a mystery. Now several studies provide evidence that non-coding transcription, often proposed to play a role, is indeed an important driver, and furthermore has a specific nuclear destination for recombination. Both local transcription-independent looping and longer range factor-mediated transcription-dependent looping play separate roles in altering AgR architecture to enable V(D)J recombination.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available