Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 22, Issue 4, Pages 354-360Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.04.002
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Funding
- NIH [R01 GM51186]
- ERC
- DKFZ
- University of Texas, Southwestern Medical Center
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Epithelial cells of the digestive tracts of most animals are short-lived, and are constantly replenished by the progeny of long-lived, resident intestinal stem cells. Proper regulation of intestinal stem cell maintenance, proliferation and differentiation is critical for maintaining gut homeostasis. Here we review recent genetic studies of stem cell-mediated homeostatic growth in the Drosophila midgut and the mouse small intestine, highlighting similarities and differences in the mechanisms that control stem cell proliferation and differentiation.
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