Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 22, Issue 1, Pages 21-27Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.01.004
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Funding
- Dutch Cancer Society (KWF)
- Netherlands Organization of Scientific Research (NWO)
- Top Institute Pharma
- Centre for Translational Molecular Medicine (CTMM)
- Cancer Systems Biology Center
- European Commission
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Genetically engineered mouse models (GEMMs) have contributed greatly to the field of cancer research. In contrast to tumor cell transplantation models, GEMMs have the potential to capture both the cell-intrinsic and cell-extrinsic factors that drive de nova formation of autochthonous tumors and their progression toward metastatic disease. In addition, GEMMs provide experimentally tractable in vivo platforms for validating candidate cancer genes, determining therapy efficacy, and defining mechanisms of drug resistance. Studies in GEMMs of human cancer provide new insight in the molecular biology of cancer and contribute to development of novel therapeutic strategies that may ultimately lead to more cures rather than temporal remissions.
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