Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 22, Issue 5, Pages 423-428Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.09.004
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Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01020106]
- National Natural Science Foundation of China [31071309]
- Ministry of Science and Technology of China 973 program [2011CB965200]
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The epithelial-to-mesenchymal transition (EMT) is a process that confers migratory characteristics to epithelial cells. It is a major force driving embryonic development, tissue fibrosis and malignant progression, and can also create cells with properties of stem cells. The mesenchymal-to-epithelial transition (MET) has the opposite course and frequently coexists with the EMT, but the underlying mechanisms are less well studied. The recent discovery that the MET is required for transforming somatic cells into pluripotent stem cells suggests that the intersection between EMT and MET is a fundamental crossroad for cell fate decisions. Further understanding of the molecular events controlling both situations has relevant implications for regenerative medicine and disease.
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