Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 22, Issue 5, Pages 409-415Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2012.08.002
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Funding
- Pew Charitable Trusts
- NIH [U01ES017155, P01GM099117]
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Reprogramming of a somatic nucleus to an induced pluripotent state can be achieved in vitro through ectopic expression of Oct4 (Pou5f1), Sox2, Klf4 and c-Myc. While the ability of these factors to regulate transcription in a pluripotent context has been studied extensively, their ability to interact with and remodel a somatic genome remains underexplored. Several recent studies have begun to provide mechanistic insights that will eventually lead to a more rational design and improved understanding of nuclear reprogramming.
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