Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 21, Issue 2, Pages 140-146Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.01.015
Keywords
-
Categories
Funding
- UK Medical Research Council
- EU Epigenome Network of Excellence
- MRC [MC_U120027516] Funding Source: UKRI
- Medical Research Council [MC_U120027516] Funding Source: researchfish
Ask authors/readers for more resources
The pluripotent state of embryonic stem cells is maintained by a core network of transcription factors, and by chromatin remodelling factors that support an environment permissive for transcription. Polycomb and trithorax Group proteins enable 'bivalent' chromatin to be established at lineage-specific genes within pluripotent cells that is thought to poise genes for rapid activation upon induction of differentiation. As differentiation proceeds, chromatin condenses and there is a genome-wide increase in the abundance of repressive histone modifications, alterations in the subnuclear organisation of particular genomic regions, and changes in DNA methylation profiles within genes. Reprogramming of somatic cells provides a platform to investigate the role of chromatin-based factors in establishing and maintaining pluripotency.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available