Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 21, Issue 1, Pages 86-92Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2010.10.002
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Funding
- National Cancer Institute [R37 CA40099]
- Flight Attendant Medical Research Institute
- European Commission [201102, 223151]
- Robert Bosch Foundation
- M.D. Moross Cancer Institute
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The p53 tumor suppressor and its paralogs p63 and p73 are at the crux of a network modulating cellular responses against potentially tumorigenic events. p53 acts primarily as a transcription factor, regulating the expression of both coding and non-coding RNAs, as well as the activity of RNA processing complexes. In line with their anti-tumorigenic function, p53 and p63 have recently been implicated in restricting tumor cell invasion. In parallel, a growing number of non-canonical target genes have been added to the p53 repertoire. These include genes encoding for proteins that impinge on a broad spectrum of cellular functions, from cell metabolism to stem cell renewal. The p53 story is still far from being fully told.
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