Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 21, Issue 6, Pages 776-786Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2011.08.007
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Funding
- NHGRI
- NIA
- Glenn Foundation
- Smith Fellowship
- Stanford Genome Training Program
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There has been a recent explosion in the wealth of genomic data available to C. elegans researchers, as efforts to characterize gene expression and its regulators at a molecular level have borne significant fruit. Detailed measurement of gene expression at a variety of developmental stages, and in numerous individual tissues, has dramatically increased our understanding of cell-type-specific gene expression networks. Characterization of the targets of transcription factors, chromatin-binding proteins, and miRNAs has provided genome-wide insights into the mechanisms governing gene expression. Development of new techniques have allowed this characterization to begin to shift from whole-organism studies to tissue-level, and even single-cell-level profiling, creating a first glimpse into gene regulatory circuits at the single-cell level in a living organism. Integration of these datasets has yielded novel insights into evolution, gene expression regulation, and the link between sequence and phenotype.
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