Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 20, Issue 5, Pages 555-561Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2010.05.007
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Funding
- Medical Research Council UK
- Leukaemia and Lymphoma Research
- European Union
- Medical Research Council [MC_U120027516] Funding Source: researchfish
- MRC [MC_U120027516] Funding Source: UKRI
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Cohesin complexes hold sister chromatids together, which is essential for proper chromosome segregation during cell division and for post-replicative DNA repair. Recent studies suggest that, in addition to this global role in chromosome biology, cohesin is recruited to specific chromosomal locations by CTCF, and perhaps by other sequence-specific DNA binding factors. Once in position, cohesin controls chromosome conformation at the local level. Could this be key to understanding cohesin's role in gene expression?
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