Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 20, Issue 6, Pages 619-625Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2010.09.002
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Funding
- National Institutes of Health [R01 GM62419, P01 NS39546]
- American Recovery and Reinvestment Act
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The circadian clock of the cyanobacterium Synechococcus elongatus PCC 7942 is built on a three-protein central oscillator that can be reconstituted in vitro, a redox-sensitive input for synchronization with the environment, and a bacterial two-component signal transduction pathway for global transcriptional regulation. This review covers the most recent progress in our understanding of the biological and biochemical mechanism of this bacterial clock, such as the discovery of a quinone-binding activity of the oscillator protein KaiA, the molecular mechanism of circadian control of cell division, and the global control of gene expression via modulation of DNA topology.
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