Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 20, Issue 1, Pages 100-104Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.10.008
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Funding
- Tumor Immunology Training [5-T32-CA009120-34]
- US National Institutes of Health [T32 GM08042]
- UCLA Medical Scientist Training Program and Interdisciplinary Training ill Virology and Gene Therapy [T32 A1065067]
- National Cancer Institute [5U54 CA119347]
- In Vivo Cellular and Molecular Imaging Centers (ICMIC) [NIH P50 CA86306]
- CIRM
- Dana Foundation
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Cancer cells and immune cells modulate their metabolism according to specific needs during cancer progression and immune responses. The ability to measure cellular metabolic function in vivo would enable the evaluation of tumors and their response to therapy and also the effectiveness of cellular immune responses to cancer. Positron emission tomography (PET) is a highly sensitive clinical imaging modality that enables whole-body, quantitative measurements of tissue biochemical function. Here, we review work using PET probes for specific metabolic pathways to measure cell function in cancer and immunity. We focus on the use of probes for glycolysis and nucleoside salvage and then discuss the development of new metabolic probes that visualize distinct parameters of cell function during disease.
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