Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 4, Pages 315-322Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.05.004
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Funding
- EMBO LTF
- FEBS fellowship
- MRC (UK)
- Wellcome Trust
- Medical Research Council [MC_U117560541] Funding Source: researchfish
- MRC [MC_U117560541] Funding Source: UKRI
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Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent Studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.
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