Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 3, Pages 254-265Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.03.008
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Funding
- Medical Research Council [G0701075] Funding Source: researchfish
- Parkinson's UK [G-0907] Funding Source: researchfish
- MRC [G0701075] Funding Source: UKRI
- Medical Research Council [G0701075] Funding Source: Medline
- Parkinson's UK [G-0907] Funding Source: Medline
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Genetic analysis has identified many loci designated as PARK loci (OMIM #168600). Many of these loci do not refer to idiopathic Parkinson's disease which is characterized by Lewy body pathology, but rather to clinical parkinsonisms. In this review, besides reviewing the genetic of the disorder, we argue that this designation is misleading and that if we seek to understand the pathogenesis, we should study the genetics of Lewy body diseases: these include not only idiopathic Parkinson's disease, but also such disparate syndromes as Hallevorden-Spatz disease and Niemann-Pick Type C.
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