Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 2, Pages 187-191Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.01.005
Keywords
-
Categories
Funding
- EU [LSHG-CT-2004-503433]
- UK Medical Research Council
- James S McDonnell foundation
- Medical Research Council [MC_U127527202] Funding Source: researchfish
- MRC [MC_U127527202] Funding Source: UKRI
Ask authors/readers for more resources
The nuclear periphery has conventionally been considered as a zone of Inactive chromatin and transcriptional repression. Recent studies have shed new light oil the types of sequences associated with proteins of the nuclear periphery in mammalian cells and have investigated the functional significance of artificially locating genes there. The results of these studies reveal a complex picture. Whilst the edge of the nucleus does seem to have a direct effect on the expression of some genes, other genes seem unaffected by their proximity to the nuclear periphery. Moreover, the nuclear periphery itself is heterogeneous, with microdomains of differing compositions, associating with different genomic regions and probably having differential effects oil genome function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available