Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 3, Pages 205-211Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.04.002
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Funding
- National Institutes of Health
- Donald W Reynolds Clinical Cardiovascular Research Center
- Sandler Foundation for Asthma Research
- Robert A Welch Fouridation
- American Heart Association
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL077439, R01HL093039] Funding Source: NIH RePORTER
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The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17-92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.
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