Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 3, Pages 271-278Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.04.004
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Funding
- NICHD NIH HHS [P50 HD055784, P50 HD055784-01, T32 HD007032-30, T32 HD007032, P-50 HD055784-01, T-32 HD0703230] Funding Source: Medline
- NIMH NIH HHS [R01 MH081754, R0-1 MH81754-01, R01 MH081754-01] Funding Source: Medline
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The autism spectrum disorders (ASD) are a heterogeneous set of developmental disorders characterized at their core by deficits in social interaction and communication. Current psychiatric nosology groups this broad set of disorders with strong genetic liability and multiple etiologies into the same diagnostic category. This heterogeneity has challenged genetic analyses. But shared patient resources, genomic technologies, more refined phenotypes, and novel computational approaches have begun to yield dividends in defining the genetic mechanisms at work. Over the last five years, a large number of autism susceptibility loci have emerged, redefining our notion of autism's etiologies, and reframing how we think about ASD.
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