Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 19, Issue 5, Pages 497-503Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2009.07.002
Keywords
-
Categories
Funding
- Medical Research Council [MC_U117560477] Funding Source: Medline
- MRC [MC_U117560477] Funding Source: UKRI
Ask authors/readers for more resources
Growth and patterning of the vertebrate limb relies on signals produced by three discrete signalling centres: the Apical Ectodermal Ridge (AER), the Zone of Polarising Activity (ZPA) and the dorsal ectoderm. The molecular identities of these signals and their associated downstream pathways have begun to be uncovered. In this review, we focus on recent work that has highlighted the importance of cross-talk between these signalling centres and how mesenchymal progenitors integrate multiple signalling inputs. We also discuss recent evidence suggesting how modulations of key signalling pathways have been used to generate the morphological diversity seen between different vertebrate limb appendages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available