Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 1, Pages 54-61Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.02.003
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Funding
- NCI NIH HHS [P01 CA104838, P01 CA104838-04] Funding Source: Medline
- NIDDK NIH HHS [K08 DK072565] Funding Source: Medline
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Tumor cells display increased metabolic autonomy in comparison to non-transformed cells, taking up nutrients and metabolizing them in pathways that support growth and proliferation. Classical work in tumor cell metabolism focused on bioenergetics, particularly enhanced glycolysis and suppressed oxidative phosphorylation (the 'Warburg effect'). But the biosynthetic activities required to create daughter cells are equally important for tumor growth, and recent studies are now bringing these pathways into focus. In this review, we discuss how tumor cells achieve high rates of nucleotide and fatty acid synthesis, how oncogenes and tumor suppressors influence these activities, and how glutamine metabolism enables macromolecular synthesis in proliferating cells.
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