Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 5, Pages 418-425Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.07.017
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Funding
- MRC [G0700213] Funding Source: UKRI
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [R37HD033082] Funding Source: NIH RePORTER
- Medical Research Council [G0700213] Funding Source: Medline
- NICHD NIH HHS [R37 HD033082, R37 HD033082-11, R37HD033082, R37 HD033082-12] Funding Source: Medline
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T-box transcription factor genes are widely conserved in metazoan development and widely involved in developmental processes. With the phase of T-box gene discovery winding down, the phase of transcriptional target discovery for T-box transcription factors is finally taking off and yielding rich rewards. Mutant phenotypes in mouse and zebrafish as well as morpholino studies in zebrafish have helped to link the T-box genes to a variety of signaling pathways through diverse target genes and feedback loops. Particularly in early mesoderm development, it is emerging that a network of T-box genes interacts with Wnt/beta-catenin and Notch/Delta signaling pathways, among others, to control the important processes of mesoderm specification, somite segmentation, and left/right body axis determination.
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