Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 2, Pages 204-211Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.01.021
Keywords
-
Categories
Funding
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG000747] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061169, R01GM066272] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01HG00747, R01 HG000747] Funding Source: Medline
- NIGMS NIH HHS [R01 GM066272, R01 GM061169, R01 GM061169-04] Funding Source: Medline
Ask authors/readers for more resources
In this review we summarize recent studies that demonstrate the importance of epigenetic mechanisms for maintaining genome integrity, specifically with respect to repeated DNAs within heterochromatin. Potential problems that arise during replication, recombination, and repair of repeated sequences are counteracted by post-translational histone modifications and associated proteins, including the cohesins. These factors appear to ensure repeat stability by multiple mechanisms: suppressing homologous recombination, controlling the three-dimensional organization of damaged repeats to reduce the probability of aberrant recombination, and promoting the use of less problematic repair pathways. The presence of such systems may facilitate repeat and chromosome evolution, and their failure can lead to genome instability, chromosome rearrangements, and the onset of pathogenesis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available