Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 5, Pages 426-434Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.07.018
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Funding
- NHLBI NIH HHS [K08 HL079172, K08 HL079172-04] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K08HL079172] Funding Source: NIH RePORTER
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Skeletal muscle adapts to physiological demands by altering a number of programs of gene expression, including those driving mitochondrial biogenesis, angiogenesis, and fiber composition. Recently, the PGC-1 transcriptional coactivators have emerged as key players in the regulation of these adaptations. Many signaling cascades important in muscle physiology impinge directly on PGC-1 expression or activity. In turn, the PGC-1s powerfully activate many of the programs of muscle adaptation. These findings have implications for our understanding of muscle responses to physiological conditions like exercise, as well as in pathological conditions such as cachexia, dystrophy, and peripheral vascular disease.
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