Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 6, Pages 571-582Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.10.002
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Funding
- CCT
- MMB
- Schlumberger Ltd
- Fundacao para a Ciencia e Tecnologia [SFRH/BD/33205/2007]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/33205/2007] Funding Source: FCT
- Medical Research Council [MC_U120061476, MC_U105185859] Funding Source: researchfish
- MRC [MC_U120061476, MC_U105185859] Funding Source: UKRI
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Recent advances in molecular techniques and high-resolution imaging are beginning to provide exciting insights into the higher order chromatin organization within the cell nucleus and its influence on eukaryotic gene regulation. This improved understanding of gene regulation also raises fundamental questions about how spatial features might have constrained the organization of genes on eukaryotic chromosomes and how mutations that affect these processes might contribute to disease conditions. In this review, we discuss recent studies that highlight the role of spatial components in gene regulation and their impact on genome evolution. We then address implications for human diseases and outline new directions for future research.
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