Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 18, Issue 4, Pages 304-310Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.gde.2008.06.001
Keywords
-
Categories
Funding
- NIH [HD21502-21]
- Howard Hughes Medical Institute
Ask authors/readers for more resources
The intensity of the BMP signal is determined by cell surface receptors that phosphorylate Smad1/5/8 at the C-terminus. In addition to this BMP-activated phosphorylation, recent studies have shown that sequential phosphorylations by MAPK and GSK3 kinases can negatively regulate the activity of the pSmad1(Cter) signal. These phosphorylations in the linker region cause Smad1 to be transported to the centrosomal region, polyubiquitinylated and degraded by the proteasomal machinery. In Xenopus embryos, Writ signals, which regulate GSK3, induce ectoderm to adopt an epidermal fate, and this Writ effect requires an active BMP-Smad1/5/8 signaling pathway. These findings have profound implications for. understanding how dorsal-ventral and anterior-posterior patterning are seamlessly integrated in the early embryonic morphogenetic field.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available